Reformatsky enolates are less reactive than lithium enolates or Grignard reagents and hence nucleophilic addition to the ester group does not occur.
22.
Because the dimethylamide anion is a poor leaving group, the intermediate does not collapse and another nucleophilic addition does not occur.
23.
The term is also applied to certain nucleophilic addition reactions, such as in the acid catalyzed hydrolysis of nitriles to amides.
24.
Nucleophilic addition does not occur if kCO * ( the effective force constant for the CO ligand ) is below a threshold value
25.
The Mannich reaction is an example of nucleophilic addition of an amine to a carbonyl group followed by dehydration to the Schiff base.
26.
X-ray diffraction confirms sp2 hybridization at boron and its nucleophilic addition reaction with benzaldehyde gives further proof of the proposed structure.
27.
This mechanism can be referred to as an instance of the ANRORC mechanism : nucleophilic addition ( A N ), ring closing.
28.
The reaction type is nucleophilic addition of sulfur to a metal carbene formed from the diazoalkane followed by a Stevens-like rearrangement.
29.
Organometallic compounds, such as organolithium reagents, Grignard reagents, or acetylides, undergo nucleophilic addition reactions, yielding a substituted alcohol group.
30.
The nucleophilic addition at ethyl acrylate as an ?, ?-unsaturated carbonyl compound is a frequent strategy in the synthesis of pharmaceutical intermediates.
