| 21. | Chromosomes are packaged by wrapping 147 nucleotides around an octamer of histone proteins, forming a nucleosome.
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| 22. | There are also proteins involved in reassembling histones behind the replication fork to reestablish the nucleosome conformation.
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| 23. | NBP-45 binds specifically to nucleosome core particles, and can function as a transcriptional activator.
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| 24. | Nucleosome core particles are observed when chromatin in interphase is treated to cause the chromatin to unfold partially.
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| 25. | Nucleosome remodeling has been found to cause, for instance, epigenetic silencing of DNA repair gene MLH1.
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| 26. | Specific remodeling proteins are constantly altering the chromatin structure by breaking the bonds between the DNA and nucleosome.
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| 27. | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes.
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| 28. | Histone H1 locks the nucleosome complex together, and it is the last protein to bind in the complex.
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| 29. | Chromatin subunit models as well as the notion of the nucleosome were established in 1973 and 1974, respectively.
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| 30. | A year later, she published a paper describing the opposing effects of H1 and HMGB1 on the nucleosome.
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