Metastatic breast cancer in bone has the ability to cause bone cells to change from those that create bone to those that break it down ( osteoclasts ) resulting in osteolysis and pathological fractures . ( see and ref . 16 ) According to a recent general review of the mechanisms of cancer pain [ http : / / www . ncbi . nlm . nih . gov / pmc / articles / PMC2895277 / ? tool = pubmed, breast cancer sufferers will almost certainly " not " feel pain in the breast, but rather usually feel the pain when metastasis occurs to the skeleton.
