Src kinase is inhibited by-pump, while, upon ouabain binding, the Src kinase domain will be released and then activated.
22.
However, this possibility was excluded by the synthesis of the 11 epimer and the demonstration that it has different chromatographic behavior from ouabain.
23.
Research suggests that the immunoassays previously used to quantify the endogenous ouabain detected other compounds as well and this cross reactivity would have produced invalid results.
24.
Another argument against endogenous ouabain was the lack of effect when rostafuroxin, a drug that selectively displaces ouabain from the ATPase receptor, was administered.
25.
Another argument against endogenous ouabain was the lack of effect when rostafuroxin, a drug that selectively displaces ouabain from the ATPase receptor, was administered.
26.
At this stage Skou was unaware that ouabain inhibited the pump, but he immediately telephoned to his lab and arranged for the experiment to be done.
27.
At micromolar concentrations, quinidine inhibits Na + / K +-ATPase by binding to the same receptor sites as the digitalis glycosides such as ouabain.
28.
Plants from this genus produce toxic alkaloids and cardiac glycosides g-strophanthin ( syn . ouabain ), k-strophanthin, and e-strophanthin.
29.
In 1882, ouabain was first isolated from the plant by the French chemist L�on-Albert Arnaud as an amorphous substance, which he identified as a glycoside.
30.
Another interpretation of the analytical data led to the proposal that endogenous ouabain may have been the 11 epimer, i . e ., an isomer of plant ouabain.
