In human " CERK ", a retinoic acid response element ( RARE )-like exists between-40bp and-28bp and contains the sequence : TCCCCG C CGCCCG . RARE-like plays a role in transcription regulation of CERK . It is suspected that in the presence of all-trans retinoic acid ( ATRA ), chicken ovalbumin upstream promoter transcription factor I ( COUP-TFI ), retinoic acid receptor ( RAR ? ), retinoid X receptor ( RXR ? ) bind the RARE-like of CERK in 5H-SY5Y cells.
22.
A critical portion of the molecule, the reactive center loop connects beta sheets A and C . Protease inhibitor-10 ( PI10; SERPINB10 ) is a member of the ov-serpin subfamily, which, relative to the archetypal serpin PI1 ( MIM 107400 ), is characterized by a high degree of homology to chicken ovalbumin, lack of N-and C-terminal extensions, absence of a signal peptide, and a serine rather than an asparagine residue at the penultimate position ( summary by Bartuski et al ., 1997 [ PubMed 9268635 ] ).
23.
In a mice model of ovalbumin-induced allergic airway disease, 12-HHT and its companion cyclooxygenase metabolites, Prostaglandin E2 and Prostaglandin D2, but not 12 other lipoxygenase or cycloxygenase mebolites showed a statistically significantly increase in bronchoalveolar lavage fluid levels after intratracheal ovalbumin challenge; after this challenge, only 12-HHT, among the monitored BLT2 receptor-activating ligands ( LTB4, the 12 ( " S " ) stereoisomer of 12-HETE, and 15 ( " S " )-HETE ) attained levels capable of activating BLT2 receptors.
24.
In a mice model of ovalbumin-induced allergic airway disease, 12-HHT and its companion cyclooxygenase metabolites, Prostaglandin E2 and Prostaglandin D2, but not 12 other lipoxygenase or cycloxygenase mebolites showed a statistically significantly increase in bronchoalveolar lavage fluid levels after intratracheal ovalbumin challenge; after this challenge, only 12-HHT, among the monitored BLT2 receptor-activating ligands ( LTB4, the 12 ( " S " ) stereoisomer of 12-HETE, and 15 ( " S " )-HETE ) attained levels capable of activating BLT2 receptors.
25.
However, in a mouse model of ovalbumin-induced allergic airway disease : "'a ) "'12-HHT and its companion cyclooxygenase metabolites, Prostaglandin E2 and Prostaglandin D2, but not 12 other lipoxygenase or cyclooxygenase metabolites showed a statistically significantly increase in bronchoalveolar lavage fluid levels after intratracheal ovalbumin challenge; "'b ) "'only 12-HHT, among the monitored BLT2 receptor-activating ligands ( i . e . LTB4, the 12 ( " S " ) stereoisomer of 12-HETE, and 15 ( " S " )-HETE ) rose to a level capable of activating BLT2 receptors; and "'c ) "'
26.
However, in a mouse model of ovalbumin-induced allergic airway disease : "'a ) "'12-HHT and its companion cyclooxygenase metabolites, Prostaglandin E2 and Prostaglandin D2, but not 12 other lipoxygenase or cyclooxygenase metabolites showed a statistically significantly increase in bronchoalveolar lavage fluid levels after intratracheal ovalbumin challenge; "'b ) "'only 12-HHT, among the monitored BLT2 receptor-activating ligands ( i . e . LTB4, the 12 ( " S " ) stereoisomer of 12-HETE, and 15 ( " S " )-HETE ) rose to a level capable of activating BLT2 receptors; and "'c ) "'
