These studies have provided evidence that the role of IRGs may prove to be not only spatially and temporally regulated in a highly coordinated manner, but that they have context specific auxiliary roles outside of the traditional phagolysosome development and maturation.
22.
"Leishmania " amastigotes obtain all their purine sources, various vitamins and a number of essential amino acids from the phagolysosome of its host . Uptake of these substances is facilitated by proton symporters . Leishmania also obtain amino acids and heme from the proteolysis of proteins in the host phagolysosome and exogenous proteins are transported to the phagolysosome by autophagy and endocytosis.
23.
"Leishmania " amastigotes obtain all their purine sources, various vitamins and a number of essential amino acids from the phagolysosome of its host . Uptake of these substances is facilitated by proton symporters . Leishmania also obtain amino acids and heme from the proteolysis of proteins in the host phagolysosome and exogenous proteins are transported to the phagolysosome by autophagy and endocytosis.
24.
"Leishmania " amastigotes obtain all their purine sources, various vitamins and a number of essential amino acids from the phagolysosome of its host . Uptake of these substances is facilitated by proton symporters . Leishmania also obtain amino acids and heme from the proteolysis of proteins in the host phagolysosome and exogenous proteins are transported to the phagolysosome by autophagy and endocytosis.
