The suggestion by K�rner and Dewar was later confirmed in an experiment where pyridine was reduced to piperidine with sodium in ethanol.
22.
Anderson first hydrolysed piperine by alkalis into a base and an acid, which were later named piperidine and piperic acid respectively.
23.
His analysis of pyridine, piperidine and coniine paved the way for the determination of the structural relations within these three compounds.
24.
The methyl group on the piperidine ring is restored by reaction with formaldehyde and formic acid, under standard Eschweiler Clarke conditions.
25.
Lythranidine is classified as an alkaloid and it contains a piperidine group that defines the synthesis of the structure via nitrone cycloaddition.
26.
The process of apparicine dehydrogenation followed by oxidation with permanganate enables identification of the location of the two piperidine ring carbon substituents.
27.
Although, piperidine is a common organic compound, it is best known as a representative structure element within many pharmaceuticals and alkaloids.
28.
A significant industrial application of piperidine is for the production of dipiperidinyl dithiuram tetrasulfide, which is used as a rubber vulcanization accelerator.
29.
Substituted chalcones were also synthesised by piperidine-mediated condensation to avoid side reactions such as multiple condensations, polymerizations, and rearrangements.
30.
Various cyclic amine groups can act as the basic moiety and potency stays relatively unchanged for example aryl piperazine, piperidine and morpholine.
