| 21. | TPA and plasmin are the key enzymes of the fibrinolytic pathway in which tPA mediated plasmin generation occurs.
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| 22. | TPA and plasmin are the key enzymes of the fibrinolytic pathway in which tPA mediated plasmin generation occurs.
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| 23. | Moreover, plasmin induces the generation of bradykinin in mice and humans trough high molecular weight kininogen cleavage.
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| 24. | PLAT is secreted by vascular endothelial cells and acts as a serine protease that converts plasminogen to plasmin.
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| 25. | In this scenario, PAI-1 inhibits uPA via active site binding, preventing the formation of plasmin.
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| 26. | Inflammatory stimuli that activate macrophages enhance the release of active TGF-? by promoting the activation of plasmin.
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| 27. | It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.
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| 28. | The circulating enzyme plasmin, the main enzyme of fibrinolysis, cleaves the fibrin gel in a number of places.
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| 29. | The conversion of plasminogen to plasmin involves the cleavage of the peptide bond between Arg-561 and Val-562.
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| 30. | Plasmin is inactivated by proteins such as sterically shielded, thus substantially decreasing the plasmin's access to protein substrates.
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