Turner syndrome is a cause of primary amenorrhea, premature ovarian failure ( hypergonadotropic hypogonadism ), streak gonads and infertility.
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A genetic investigation was performed to test women with premature ovarian failure for mutations in each of four meiotic genes.
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After taking a blood test, the doctor said that I have premature ovarian failure and both my ovaries are not working.
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Premature ovarian failure is part of the BPES Type I variant of the syndrome but not of the BPES Type II variant.
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It is believed that premature ovarian failure in humans is caused by FIGLA haploninsuffciency, which disrupts the formation of the primordial follicles.
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Additionally, antiquitin is implicated in other diseases, including cancer, diabetes, osteoporosis, premature ovarian failure and Huntington's disease, though the exact mechanisms remain unclear.
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However, in the majority of spontaneous cases of premature ovarian failure, the cause is unknown, i . e ., it is generally idiopathic.
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Mutations of this gene can lead to fragile X syndrome, intellectual disability, premature ovarian failure, autism, Parkinson's disease, developmental delays and other cognitive deficits.
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The report was prepared by researchers for the National Institute of Child Health and Human Development, and it focused on women with premature ovarian failure.
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Known causes of premature ovarian failure include autoimmune disorders, thyroid disease, diabetes mellitus, chemotherapy, being a carrier of the fragile X syndrome gene, and radiotherapy.
