He started his research with cardiac glycosides and cardiac aglycones shifting to the synthesis of primaquine and other antimalarials, at the end he did some research in new anticancer agents
22.
An estimated 70 % of Nicaragua s total population ( 1.9 million people ) received chloroquine and primaquine during the peak period of disease transmission ( November ).
23.
Treatment of " P . vivax " requires both treatment of blood stages ( with chloroquine or ACT ) as well as clearance of liver forms with primaquine.
24.
Other medications that are used, alone or in combination, include pentamidine, trimetrexate, dapsone, atovaquone, primaquine, pafuramidine maleate ( under investigation ), and clindamycin.
25.
It is an 8-aminoquinoline, of the same family as primaquine, developed by researchers at the Walter Reed Army Institute of Research in the 1970s and tested in safety trials.
26.
Pamaquine is no longer available anywhere, but primaquine is still used routinely worldwide as part of the treatment of " Plasmodium vivax " and " Plasmodium ovale " malaria.
27.
In 1956 Alving and colleagues showed that in some African Americans the antimalarial drug primaquine induces hemolytic anemia, and that those individuals have an inherited deficiency of G6PD in erythrocytes . fava beans.
28.
There are few significant side effects although it has been shown that primaquine may cause anorexia, nausea, vomiting, cramps, chest weakness, anaemia, some suppression of myeloid activity and abdominal pains.
29.
In addition, chemoprophylaxis is started before travel, during the time of potential exposure, and for 4 weeks ( chloroquine, doxycycline, or mefloquine ) or 7 days ( atovaquone / proguanil or primaquine ) after leaving the risk area.
30.
Given in combination with lumefantrine, it may be followed by a 14 day regimen of primaquine to prevent relapse of " P . vivax " or " P . ovale " malarial parasites and provide a complete cure.
