Autoimmune conditions such as anti-p62 antibodies, which inhibit p62 complexes have links to primary biliary cirrhosis which destroys the bile ducts of the liver.
22.
For decades, people with a liver disease called primary biliary cirrhosis were told that there was little if any hope of reversing the illness.
23.
In 1966, she helped create what is now a standard test in diagnosing primary biliary cirrhosis, a rare disease that can lead to liver failure.
For example, elevated IgA indicates alcoholic cirrhosis, elevated IgM indicates viral hepatitis and primary biliary cirrhosis, while IgG is elevated in viral hepatitis, autoimmune hepatitis and cirrhosis.
26.
Variants in this gene have been associated with insulin-dependent diabetes mellitus, Graves'disease, Hashimoto's thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, primary biliary cirrhosis and other autoimmune diseases.
27.
Genentech partnered with Biogen Idec to explore the use of the drug for primary biliary cirrhosis but as of 2014 it appeared the development in that indication had halted.
28.
Her contributions to hepatology include seminal work on the natural history of autoimmune hepatitis, variant and overlap syndromes of autoimmune hepatitis, treatment of primary biliary cirrhosis and treatment of viral hepatitis.
29.
In primary sclerosing cholangitis ( PSC ) and primary biliary cirrhosis ( PBC ), the bilirubin references are changed to reflect the fact that these diseases feature high conjugated bilirubin levels.
30.
The differential diagnosis can include primary biliary cholangitis ( formerly referred to as primary biliary cirrhosis ), drug induced cholestasis, cholangiocarcinoma, IgG4-related disease, post-liver transplantation non-anastomotic biliary strictures, and HIV-associated cholangiopathy.
