Therefore, during gametogenesis, primordial germ cells must have their original biparental DNA methylation patterns erased and re-established based on the sex of the transmitting parent.
22.
By contrast, DNA methylation is dispensable in undifferentiated cell types, such as the inner cell mass of the blastocyst, primordial germ cells or embryonic stem cells.
23.
During this time primordial germ cells migrate from the yolk sac to the gonadal ridge; a region of mesenchyme arising from, and running parallel with, the mesonephros.
24.
In female mammals, meiosis begins immediately after primordial germ cells migrate to the ovary in the embryo, but in the males, meiosis begins later, at the time of puberty.
25.
Testicular cancer begins when something goes wrong in the DNA in one of the primordial germ cells _ cells that every male is born with and which later develop into sperm.
26.
This is in contrast to male primordial germ cells which are arrested in the spermatogonial stage at birth and do not enter into spermatogenesis and meiosis to produce primary spermatocytes until puberty in the adult male.
27.
Blimp1-deficient mutant embryos form a tight cluster of about 20 primordial germ cell-like cells, which fail to show the characteristic migration, proliferation and consistent repression of homeobox genes that normally accompany specification of primordial germ cells.
28.
Blimp1-deficient mutant embryos form a tight cluster of about 20 primordial germ cell-like cells, which fail to show the characteristic migration, proliferation and consistent repression of homeobox genes that normally accompany specification of primordial germ cells.
29.
During development, primordial germ cells migrate into the seminiferous tubules and downward towards the basement membrane whilst remaining attached to the sertoli cells where they will subsequently differentiate into SSCs, also referred to as Asingle spermatogonia.
30.
Blimp1 ( also known as Prdm1 ), a known transcriptional repressor, has a critical role in the foundation of the mouse germ cell lineage, as its disruption causes a block early in the process of primordial germ cell formation.
