Commands are routed though the basal ganglia and are modified by input from the cerebellum before being relayed through the pyramidal tract to the spinal cord and from there to the motor end plate at the muscles.
22.
M1 finally generates the volley for the pyramidal tract, which then enters consciousness . postulated that we do not have free will ( BP1 ) but with the control of the action ( BP2 ) we do have free will.
23.
A heterozygous deletion in GRID2 in humans causes a complicated spastic paraplegia with ataxia, frontotemporal dementia, and lower motor neuron involvement whereas a homozygous biallelic deletion leads to a syndrome of cerebellar ataxia with marked developmental delay, pyramidal tract involvement and tonic upgaze, that can be classified as an ataxia with oculomotor apraxia ( AOA ).
24.
The presence and severity of myelopathy can also be evaluated by means of Transcranial Magnetic Stimulation ( TMS ), a neurophysiological method that allows the measurement of the time required for a neural impulse to cross the pyramidal tracts, starting from the cerebral cortex and ending at the anterior horn cells of the cervical, thoracic or lumbar spinal cord.
