Each side of the dimer protein includes pyridoxal phosphate ( PLP ) bonded to the "'Lys280 "'residue of the tyrosine aminotransferase molecule.
22.
Pyridoxal phosphate ( a derivative of pyridoxine ) is required for d-aminolevulinic acid synthase, the enzyme responsible for the rate-limiting step in heme synthesis.
23.
Its toxicity stems primarily from the fact that it readily forms oximes with keto acids and aldehydes, especially the pyridoxal phosphate cofactor of many vitamin B 6-dependent enzymes.
24.
Glycogen phosphorylase has a pyridoxal phosphate ( PLP, derived from S N 1 fashion, resulting in the formation of a glucose molecule with a secondary carbocation at the 1 position.
25.
In each of the 19 pathways for the generation of chiral amino acids, the stereochemistry at the ?-carbon atom is established by a transamination reaction that involves pyridoxal phosphate.
26.
The mutations T67I and Q240E weaken the enzyme's affinity for pyridoxal phosphate, the co-factor vital to enzymatic function . Propargylglycine ( acidic beta hydrogen explicitly shown ).
27.
ALT ( and all aminotransferases ) require the coenzyme pyridoxal phosphate, which is converted into pyridoxamine in the first phase of the reaction, when an amino acid is converted into a keto acid.
28.
L-Phenylalanine is converted into L-tyrosine by the enzyme phenylalanine hydroxylase, with aromatic L-amino acid decarboxylase ( also known as DOPA decarboxylase ), with pyridoxal phosphate as the cofactor.
29.
"' Pyridoxal phosphate "'( PLP, pyridoxal 5'- phosphate, P5P ), the active form of vitamin B 6, is a coenzyme in a variety of enzymatic reactions.
30.
Structures of the three main molecules involved in chemical reaction catalyzed by the tyrosine aminotransferase enzyme are shown below : the amino acid tyrosine, the prosthetic group pyridoxal phosphate, and the resulting product 4-hydroxyphenylpyruvate.
