| 21. | Zingiberene is formed in the isoprenoid pathway from farnesyl pyrophosphate ( FPP ).
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| 22. | The reaction uses thiamine pyrophosphate in order to link the two pyruvate molecules.
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| 23. | Phosphosphomevalonate decarboxylase through a concerted decarboxylation reaction affords isopentenyl pyrophosphate ( IPP ).
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| 24. | They couple pyrophosphate hydrolysis or synthesis to Na + or H + pumping.
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| 25. | The cofactor necessary for this step to occur is thiamin pyrophosphate ( TPP ).
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| 26. | GPP then loses the pyrophosphate group to form the resonance-stable geranyl cation.
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| 27. | All PRTases involve the displacement of pyrophosphate in PRPP by a variety of nucleophiles.
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| 28. | Moreover, the Lys522 sidechain also moves to neutralize the negatively charged pyrophosphate group.
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| 29. | The energy required for this linkage comes from the hydrolysis of a pyrophosphate molecule.
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| 30. | Thiamine pyrophosphate cofactor in yellow and xylulose 5-phosphate substrate in black . ()
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