Lesions in the pallidum can suppress effects of quinolinic acid in monkeys injected with quinolinic acid into their striatum.
22.
A loss of astrocytes results in a pro-inflammatory effect, further increasing the initial inflammatory response which initiates quinolinic acid production.
23.
Furthermore, quinolinic acid results in changes of the biochemistry and structure of the astrocytes themselves, resulting in an apoptotic response.
24.
It is synthesised by the oxidation of aspartate and is condensed by quinolinate synthase with glycerone phosphate to form quinolinic acid.
25.
Increased levels of quinolinic acid might contribute to the apoptosis of astrocytes and certain neurons, resulting in decreased synthesis of neurotrophic factors.
26.
High levels of quinolinic acid may be the closest thing so far to a " marker " of child abuse, Kochanek says.
27.
This is followed by a condensation with glyceraldehyde-3-phosphate and a cyclization catalyzed by quinolinate synthase ( QS ) to give quinolinic acid.
28.
Studies have demonstrated that quinolinic acid may be involved in many psychiatric disorders, neurodegenerative processes in the brain, as well as other disorders.
29.
Because quinolinic acid accumulates slowly in the brain, its presence may reveal whether a parent is lying about the timing of the injury.
30.
Quinolinic acid then reacts with phosphoriboxyl pyrophosphate catalyzed by quinolinic acid phosphoribosyl transferase ( QPT ) to form niacin mononucleotide ( NaMN ).
