| 21. | There is evidence to suggest that BLM plays a role in rescuing disrupted DNA replication at replication forks.
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| 22. | Chromosome combing allows a genome-wide view of the firing of origins and propagation of replication fork.
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| 23. | As a result, the replication forks are constrained to always meet within the termination region of the chromosome.
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| 24. | Another way to view the active helicase is its ability to directly destabilize the replication fork to promote unwinding.
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| 25. | Heading towards the replication fork, the nicks ) are filled with deoxyribonucleotides and sealed by the enzyme ligase.
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| 26. | This asymmetry is due the formation of the replication fork and its division into nascent leading and lagging strands.
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| 27. | A number of proteins are associated with the replication fork to help in the initiation and continuation of DNA synthesis.
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| 28. | The DnaB helicases loaded onto the two DNA strands thus travel in opposite directions, creating two potential replication forks.
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| 29. | GINS are one of the replication proteins found at the replication forks and forms a complex with Cdc45 and Mcm.
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| 30. | The clustering do "'rescue of stalled replication forks "'and favors normal progress of replication forks.
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