"' Rheumatoid factor "'( RF ) is the autoantibody ( antibody directed against an organism's own tissues ) that was first found in rheumatoid arthritis.
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Detection of specific autoantibodies ( antibodies directed against the body s own tissue ) such as rheumatoid factors and ACPAs may provide indication of the disease.
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This assay combines the detection of rheumatoid factor and anti-MCV for diagnosis of RA and shows a sensitivity of 72 % and specificity of 99.7 %.
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This assay combines the detection of rheumatoid factor and anti-MCV for diagnosis of rheumatoid arthritis and shows a sensitivity of 72 % and specificity of 99.7 %.
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Most significant to researchers, patients in both studies who took minocycline had profound decreases in rheumatoid factor, the circulating antibodies thought to give rise to joint destruction.
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"Seronegative " refers to the fact that these diseases are negative for rheumatoid factor, indicating a different pathophysiological mechanism of disease than what is commonly seen in rheumatoid arthritis.
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The presence of rheumatoid factor in serum can also indicate the occurrence of suspected autoimmune activity unrelated to rheumatoid arthritis, such as that associated with tissue or organ rejection.
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"' Lupus vasculitis "'is a complication of Systemic Lupus Erythematosus in which the autoimmune response causes the deposition of immune complexes, such as rheumatoid factor, within the blood vessels.
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The study hypothesized that some unidentified ingredient in coffee may trigger the production of rheumatoid factor, an antibody that can be detected in the blood years before the onset of arthritis.
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An ELISA technique for CMV-specific IgM is available, but may give false-positive results unless steps are taken to remove rheumatoid factor or most of the IgG antibody before the serum sample is tested.
