Previously designed compounds were charged molecules that are not absorbed well in the gastrointestinal tract and therefore did not reach high serum concentrations.
22.
After a single dose intramuscular administration, the peak serum concentration typically occurs at about 60 minutes after the dose is administered, or earlier.
23.
Immunodeficiency is a consistent feature with low serum concentrations of immunoglobulins which may improve with age and a poor immunological response to childhood vaccination.
24.
In contrast to Hp Hb, the Hpr Hb complex does not bind CD163 and the Hpr serum concentration appears to be unaffected by haemolysis.
25.
Fluvoxamine has been observed to increase serum concentrations of mirtazapine, which is mainly metabolized by CYP1A2, CYP2D6, and CYP3A4, by 3-to 4-fold in humans.
26.
Dosage adjustments may be considered, and when possible, serum concentrations of drugs primarily metabolized by CYP3A should be monitored closely in patients concurrently receiving erythromycin.
27.
For vigabatrin, there is no range of target concentrations because researchers found no difference between the serum concentration levels of responders and those of non-responders.
28.
Aluminum phosphate and aluminum hydroxide can cause decreases in the absorption of Chlortetracycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
29.
"The study suggested that the Genentech material achieved a slightly higher serum concentration than the Xoma material, " the companies said in a joint release.
30.
Co-administration of atorvastatin with one of CYP3A4 inhibitors such as itraconazole, telithromycin, and voriconazole, may increase serum concentrations of atorvastatin, which may lead to adverse reactions.
