Because they fall into these two categories, extensive opportunities for complex interactions and varied sites of action as well as multiple molecular targets are open for consideration.
22.
She has written extensively on the ways in which new communication technologies can change definitions and perceptions of social actors, social groups, and appropriate sites of action.
23.
Production of mevalonate is the rate-limiting and irreversible step in cholesterol synthesis and is the site of action for statins ( a class of cholesterol lowering drugs ).
24.
For example, protein drugs such as insulin may be circulation if taken orally; these effects are greatly reduced by inhaling smaller doses direct to the required site of action.
25.
This is partly because most of the anesthetic is ionized and therefore unable to cross the cell membrane to reach its cytoplasmic-facing site of action on the sodium channel.
26.
Moody said there are many possible sites of action, including numerous ion channels, receptors and many proteins and enzymes that carry messages through cells and on to neighboring cells.
27.
In addition, the axon hillock also has a specialized plasma membrane that contains large numbers of voltage-gated ion channels, since this is most often the site of action potential initiation.
28.
In addition, drug interactions can occur directly at the site of action, through common pathways or indirectly through metabolism of the drug in the liver or through elimination in the kidney.
29.
The upper molecular-weight limit for a small molecule is approximately 900 daltons, which allows for the possibility to rapidly diffuse across cell membranes so that they can reach intracellular sites of action.
30.
The mutated protein, but not the wild-type transporter, transports chloroquine when expressed in " Xenopus " oocytes and is thought to mediate chloroquine leak from its site of action in the digestive vacuole.
