The formula of suramin was kept secret by Bayer for commercial reasons; however, it was elucidated and published in 1924 by Ernest Fourneau and his team of the Pasteur Institute.
22.
By 1922, Suramin was generally combined with tryparsamide ( another pentavalent organoarsenic drug ), the first drug to enter the nervous system and be useful in the treatment of the second stage of the gambiense form.
23.
Activation of on cells by ATP was reversed by using the P2 antagonists suramin and pyridoxal-phosphate-6-azophenyl-22, 42 disulphonic acid ( PPADS ), but not with the P2Y antagonist MRS2179.
24.
P2X 7 receptors are sensitive to pyridoxalphosphate-6-azophenyl-2', 4'- disulphonic acid ( PPADS ) and relatively insensitive to suramin, but the suramin analog, NF279, is much more effective.
25.
P2X 7 receptors are sensitive to pyridoxalphosphate-6-azophenyl-2', 4'- disulphonic acid ( PPADS ) and relatively insensitive to suramin, but the suramin analog, NF279, is much more effective.
26.
Late diagnosis of renal failure usually means dialysis and eventual transplant, and with diabetic end-stage renal disease increasing and representing more than ~ 10 % of Medicare s budget, suramin may be the inexpensive solution we seek.
27.
Different subunits exhibit different sensitivities to purinergic agonists such as ATP, ?, ?-meATP and BzATP; and antagonists such as pyridoxalphosphate-6-azophenyl-2', 4'- disulphonic acid ( PPADS ) and suramin.
28.
Korrapati, M . C ., B . E . Shaner and R . G . Schnellmann ( 2012 ) . " Recovery from glycerol-induced acute kidney injury is accelerated by suramin . " J Pharmacol Exp Ther 341 ( 1 ) : 126-136.
