Ratios of relative responses, often summarized using the concept therapeutic index, are utilized to help understand and communicate treatment responses.
22.
Because of the wide therapeutic index of the SSRIs, most patients will have mild or no symptoms following moderate overdoses.
23.
Tricyclics have a narrow therapeutic index, " i . e . ", the therapeutic dose is close to the toxic dose.
24.
Strychnine can also be used as a medication-however it has an extremely low therapeutic index and better, less toxic replacements are available.
25.
One of the most basic pharmacological strategies used in evaluating agents is called Therapeutic Index and can be applied in many ways.
26.
Thus, the protective index is a more accurate measure of the benefit-to-risk ratio than the therapeutic index, but is less objectively defined.
27.
Therefore, it is more useful to compare such substances by therapeutic index, which is simply the ratio of LD 50 to ED 50.
28.
The therapeutic index is way too small and even supposedly " safe " doses for one person may end up killing another person.
29.
Because tricyclic antidepressants have a relatively narrow therapeutic index, the likelihood of serious overdose ( both accidental and intentional ) is fairly high.
30.
Theophylline has a very narrow therapeutic index, so its dosages must be supervised by direct measurement of serum theophylline levels to avoid toxicity.
