In thrombotic thrombocytopenic purpura ( TTP ) and hemolytic uremic syndrome ( HUS ), ADAMTS13 either is deficient or has been inhibited by antibodies directed at the enzyme.
22.
It is deficient or defective in von Willebrand disease and is involved in a large number of other diseases, including thrombotic thrombocytopenic purpura, Heyde's syndrome, and possibly hemolytic-uremic syndrome.
23.
There are disorders that reduce the number of platelets, such as heparin-induced thrombocytopenia ( HIT ) or thrombotic thrombocytopenic purpura ( TTP ), that typically cause thromboses, or clots, instead of bleeding.
24.
Pre-eclampsia can mimic and be confused with many other diseases, including chronic hypertension, chronic renal disease, primary seizure disorders, gallbladder and pancreatic disease, immune or thrombotic thrombocytopenic purpura, antiphospholipid syndrome and hemolytic-uremic syndrome.
25.
Plasmapheresis of the autologuous and exchange types is used to treat a variety of disorders, including those of the immune system, such as Goodpasture's syndrome, myasthenia gravis, Guillain Barr?syndrome, lupus, and thrombotic thrombocytopenic purpura.
26.
However, because of its rare but serious side effects of neutropenia and thrombotic thrombocytopenic purpura it was primarily used in patients in whom aspirin was not tolerated, or in whom dual antiplatelet therapy was desirable.
27.
Other conditions flagged by experts consistently are chemical toxicity; a rare blood condition called thrombotic thrombocytopenic purpura, or TTP, which can be triggered by an infection or cancer and a pre-leukemia bone marrow problem called myelodysplasia.
28.
Non-infectious diseases that may result in symptoms similar to those of EVD include acute promyelocytic leukemia, hemolytic uremic syndrome, snake envenomation, clotting factor deficiencies / platelet disorders, thrombotic thrombocytopenic purpura, hereditary hemorrhagic telangiectasia, Kawasaki disease, and warfarin poisoning.
29.
Valacyclovir, a pro-drug of acyclovir likely to be just as effective for ocular disease, can cause thrombotic thrombocytopenic purpura / Hemolytic-uremic syndrome in severely immunocompromised patients such as those with AIDS; thus, it must be used with caution if the immune status is unknown.
30.
Decreased platelet numbers may be due to various causes, including insufficient production ( e . g ., in myelodysplastic syndrome or other bone marrow disorders ), destruction by the immune system ( immune thrombocytopenic purpura / ITP ), and consumption due to various causes ( thrombotic thrombocytopenic purpura / TTP, hemolytic-uremic syndrome / HUS, paroxysmal nocturnal hemoglobinuria / PNH, disseminated intravascular coagulation / DIC, heparin-induced thrombocytopenia / HIT ).
