They are the only two insect repellents approved by the Environmental Protection Agency for topical application to humans.
22.
Dermal anesthesia can also be achieved without needles by the topical application of local anesthetics or by lidocaine iontophoresis.
23.
Since the 16th century, thyme oil has been used for its antiseptic properties, both as mouthwash and for topical application.
24.
While fluoridated toothpaste and mouthwash are widely available, dentists argue that such topical applications are much less effective than ingestion.
25.
Topical application of some pharmaceuticals has merit, but requires repeated, persistent applications and is less effective than some systemic treatments.
26.
Clinical studies have shown systemic absorption of clindamycin through topical application, in some cases leading to diarrhea, bloody diarrhea, and colitis.
27.
Since the fungus grows on tissue surfaces rather than inside epithelial cells, topical applications of oils and other compounds are recommended.
28.
Several reports have demonstrated the efficacy of topical application of the beta-adrenergic antagonist timolol in the treatment of pediatric pyogenic granuloma.
29.
Repeated topical applications of capsaicin, are followed by a prolonged period of reduced skin sensibility referred to as desensitization, or nociceptor inactivation.
30.
While the use of any antibiotic can contribute to antibiotic resistance, localized topical applications are less frequently implicated than their systemic counterparts.
