Enzymes utilizing such cofactors include the PLP-dependent enzyme aspartate transaminase and the TPP-dependent enzyme pyruvate dehydrogenase.
22.
The engineered transaminase contained 27 individual point mutations and displayed activity four orders of magnitude greater than the parent enzyme.
23.
Excessive phenylalanine can be metabolized into phenylketones through the minor route, a transaminase pathway with phenylacetate, phenylpyruvate and phenethylamine.
24.
Finally, a transamination catalyzed either by an alanine-valine transaminase or a glutamate-valine transaminase results in valine.
25.
Finally, a transamination catalyzed either by an alanine-valine transaminase or a glutamate-valine transaminase results in valine.
26.
Crystal structures of L-lysine 6-transaminase reveal a Glu243 switch through which the enzyme changes substrate specificities.
27.
Laboratory tests may show an increase in alanine transaminase ( ALT ), hematuria, glycosuria, and an increase in lipase.
28.
The most common therapeutic agent available for SSADH deficiency is one that reduces the levels of GHB via inhibition of GABA transaminase.
29.
GABA is metabolized by successive transamination and oxidation to yield succinic semialdehyde and succinic acid respectively via the catalyzing effects of GABA transaminase.
30.
It is formed from GABA by the action of GABA transaminase and further oxidised to become succinic acid, which enters TCA cycle.
