The genome consists ( in this order ) of an LH terminal domain, a pathogenic domain, conserved central domain, variable domain, and an RH terminal domain . " Pospiviroidae " replication occurs in an asymmetric fashion via host cell RNA polymerase, RNase, and RNA ligase.
22.
A semantics for open formulas cannot be given in the form of a Tarskian semantics ( ); an adequate semantics must specify what it means for a formula to be satisfied by a set of assignments of common variable domain ( a " team " ) rather than satisfaction by a single assignment.
23.
The variable domain of both the TCR ?-chain and ?-chain each have three hypervariable or complementarity determining regions ( CDRs ), whereas the variable region of the ?-chain has an additional area of hypervariability ( HV4 ) that does not normally contact antigen and, therefore, is not considered a CDR.
24.
Class switching occurs after activation of a mature B cell via its membrane-bound antibody molecule ( or B cell receptor ) to generate the different classes of antibody, all with the same variable domains as the original antibody generated in the immature B cell during the process of V ( D ) J recombination, but possessing distinct constant domains in their heavy chains.
25.
A "'single-domain antibody "'( "'sdAb "', called "'Nanobody "'by Ablynx, the developer ) is an antibody fragment consisting of a single monomeric light chains, and even smaller than Fab fragments ( ~ 50 kDa, one light chain and half a heavy chain ) and single-chain variable fragments ( ~ 25 kDa, two variable domains, one from a light and one from a heavy chain ).
