SFRP1 has been shown to have a role in new vascularization after an ischemic event and as a potent angiogenic factor.
22.
Both enzymes inhibit bFGF induced vascularization in the corneal pocket assay and inhibit VEGF induced angiogenesis in the chorioallantoic membrane assay.
23.
The simultaneous inhibition of these targets therefore leads to both reduced tumor vascularization and cancer cell death, and ultimately tumor shrinkage.
24.
Yet, when it is in conjunction with vascular endothelial growth factors, or VEGF, it can promote neo-vascularization.
25.
In vitro and in vivo mouse studies have shown membrane bound NRP1 to be proangiogenic and promotes the vascularization of prostate tumors.
26.
The increase in vascularization allows increases anastomization ( redundant blood flow ) and imparts resistance to ischemia ( loss of blood perfusion ).
27.
The connection between breast tumors and vascularization was highlighted and studied in detail by Judah Folkman in his research on angiogenesis which began in 1965.
28.
However, some pachycephalosaurs such at " Stygimoloch " have vascularization in the skull cap that would not have supported head-butting behavior.
29.
Instead of just recording the change in heat generated by the tumor, the image is now able to identify changes due to the vascularization of the mammary gland.
30.
In normal individuals, the cornea is hypoxia ( such as that occurring with overuse of contact lenses ) or inflammation may lead to peripheral corneal vascularization, or pannus.
