His subsequent investigations showed that the early biochemical effect of the two epipodophyllotoxins on proliferating cells in-vitro differed from the alkylating agents, antimetabolites and vinca alkaloids.
22.
Vinca alkaloids bind to the tubulin with high affinity at the microtubule ends but with low affinity at the tubulin sites present along the sides of the microtubule cylinder.
23.
"Catharanthus roseus ", known formerly as " Vinca rosea ", is a main source of vinca alkaloids, now sometimes called catharanthus alkaloids.
24.
So the vinca alkaloids do much more damage to the lymphoid cell lines ( including the T-cell lines responsible for antileukemic immunity ) than to the myeloid cell lines.
25.
Moreover, vinca alkaloids in the context of AML cause AML cells to undergo a cell cycle arrest in the phase that renders those cells less sensitive to cytarabine and anthracyclines.
26.
The antitumour effect of the vinca alkaloids ( e . g . vincristine ) was later shown to be due to their ability to inhibit microtubule polymerization alkaloys, and therefore cell division.
27.
Vincaminol is not as well known as some of the other Vinca alkaloids such as vinblastine, vinorelbine, vincristine, and vindesine, which are the four main, medically useful Vinca alkaloids.
28.
Vincaminol is not as well known as some of the other Vinca alkaloids such as vinblastine, vinorelbine, vincristine, and vindesine, which are the four main, medically useful Vinca alkaloids.
29.
Loganic acid is an iridoid substrate converted to strictosidine which reacts with tryptamine, eventually leading to the indole alkaloids which include many biologically active compounds such as strychnine, yohimbine, vinca alkaloids, and ellipticine.
30.
Chemotherapy drugs associated with CIPN include thalidomide, the epothilones such as ixabepilone, the vinca alkaloids vincristine and vinblastine, the taxanes paclitaxel and docetaxel, the proteasome inhibitors such as bortezomib, and the platinum-based drugs cisplatin, oxaliplatin and carboplatin.
