To do this an acylation reaction is performed, then the carbonyl is removed by clemmensen reduction or a similar process.
32.
The final peptide is often modified, e . g ., by glycosylation, acylation, halogenation, or hydroxylation.
33.
The compound is useful as a synthon for nucleophilic acylation, via deprotonation of the alkene adjacent to the oxygen attachment.
34.
Friedel developed the Friedel-Crafts alkylation and acylation reactions with James Crafts in 1877, and attempted to make synthetic diamonds.
35.
In the acylation step a haloacetic acid, typically bromoacetic acid activated by diisopropylcarbodiimide reacts with the amine of the previous residue.
36.
Even more reduction ( sodium borohydride ) and acylation resulted in epimeric di-acetate "'9 " '.
37.
The nitrile-based acylation is particularly useful because it allows direct ortho-acylation of aniline without protecting the amine group.
38.
The nitrile-based acylation is particularly useful because it allows direct ortho-acylation of aniline without protecting the amine group.
39.
The analogous acylations of amines to give amides are less sensitive because amines are stronger nucleophiles and react more rapidly than does water.
40.
Following the sub-monomer protocol originally created by Ron Zuckermann, each residue is installed in two steps : acylation and displacement.
