| 31. | In the original reaction shown in Figure 1 . naturally occurring chiral proline is the chiral catalyst in an Aldol reaction.
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| 32. | However, the aldol reaction is not formally a condensation reaction because it does not involve the loss of a small molecule.
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| 33. | For this work Mukaiyama was inspired by earlier work done by Georg Wittig in 1966 on crossed aldol reactions with lithiated imines.
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| 34. | Teruaki Mukaiyama is an expert on aldol reactions and not surprisingly his Taxol version contains no less than 5 of these reactions.
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| 35. | Additional reactions include aldol reactions, Mannich reaction, Michael reaction, amination, ?-oxyamination, and ?-halogenation.
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| 36. | Inspired by this, a modified tandem aldol reaction has been developed using the malonic acid half thioester as the enolate source.
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| 37. | To elongate the appendage by 2 carbons, acetyl-CoA is added to the aldehyde in an aldol reaction to afford prestrychnine.
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| 38. | Cooking ginger transforms gingerol via a reverse aldol reaction into zingerone, which is less pungent and has a spicy-sweet aroma.
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| 39. | Examples of chiral auxiliaries include, Evans chiral oxazolidinone auxiliaries ( for asymmetric aldol reactions ) pseudoephedrine amides and tert-butanesulfinamide imines.
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| 40. | In the highly versatile and widely used Evans Aldol Reaction, allylic strain played a major role in the development of the reaction.
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