IgE also has an essential role in type I hypersensitivity, which manifests in various allergic diseases, such as allergic asthma, most types of sinusitis, allergic rhinitis, food allergies, and specific types of chronic urticaria and atopic dermatitis.
32.
The tested indications are in the areas of allergic asthma, perennial and seasonal allergic rhinitis, peanut allergy, latex allergy, atopic dermatitis, chronic idiopathic urticaria ( also called chronic spontaneous urticaria, idiopathic anaphylaxis, mastocytosis, eosinophilic gastroenteritis, nasal polyposis, and others ).
33.
Coupled with the fact that CCL18 is highly expressed in patients with allergic asthma and other hypersensitivity diseases, Finally, CCL18 is expressed by dendritic cells in the germinal center of inflamed lymph nodes, and recruits na�ve B-cells for antigen presentation.
34.
They suggested that " hygiene and a Westernized semisterile diet " might foster allergies by changing the pattern of normal and pathogenic organisms in the gut, " thus contributing to the epidemic of allergic asthma and rhinitis in developed countries ."
35.
This was later followed by numerous other independent, some multi-center, clinical trials evaluating DNAzymes in humans, including DNAzymes targeting EBV-LMP1 in patients with nasopharyngeal cancer and DNAzymes targeting another nuclear transcription factor GATA3 in patients with allergic asthma demonstrating DNAzyme efficacy and safety.
36.
But there is a new option for the estimated half a million people with severe allergic asthma not controlled by today's medicines : Called Xolair, it's the first anti-IgE treatment, able to cut asthma attacks by about a third by blocking the IgE-caused inflammation chain reaction.
37.
"It's an excellent result, " said Dr . Mitchell Friedman, head of the lung center at Tulane University in New Orleans, who was not connected with the research . " It may transform asthma treatment, certainly in allergic asthma, but there are a whole lot of things that influence inflammation in asthma.
38.
Celltech is also developing drugs to treat rheumatoid arthritis, Crohn's disease and colitis with Bayer AG, a drug to treat allergic asthma with Schering-Plough Corp . and a treatment for leukemia with American Home Products Corp . To allay risk that accompanies drug development, Celltech generally develops drugs in collaboration with larger partners.
39.
Today, Medical Yoga Therapy is being widely used---in applicable cases---as a drugless treatment of musculoskeletal conditions such as osteoarthritis of the knee, Type 2 diabetes, bronchial / allergic asthma, etc . There are dozens of centres in India delivering this kind of yoga therapy to patients and conducting classes for students to train as therapists too.
