In investigating the regulation of muscle protein production, they observed that neither mRNA nor antisense RNA injections had an effect on protein production, but double-stranded RNA successfully silenced the targeted gene.
32.
In studies using antisense RNA, downregulation of RAB7 gene expression in HeLa cells using antisense RNA induces severe cell vacuolation that resembles the phenotype seen in fibroblasts from patients with Ch�diak Higashi syndrome.
33.
In studies using antisense RNA, downregulation of RAB7 gene expression in HeLa cells using antisense RNA induces severe cell vacuolation that resembles the phenotype seen in fibroblasts from patients with Ch�diak Higashi syndrome.
34.
In molecular biology, "'ZNRD1 antisense RNA 1 "'( non-protein coding ), also known as "'ZNRD1-AS1 "'or HTEX4, is a long non-coding RNA . In humans, it is located in the MHC class I region of chromosome 6.
35.
"' Iron stress repressed RNA "'( IsrR ) is a cis-encoded antisense RNA which regulates the expression of the photosynthetic protein isiA . IsiA expression is activated by the Ferric uptake regulator protein ( Fur ) under iron stress conditions.
36.
Human lymphoma cell proliferation ( with t ( 14; 18 ) translocation ) could be inhibited by antisense RNA targeted at the start codon region of Bcl-2 mRNA . " In vitro " studies led to the identification of Genasense, which is complementary to the first 6 codons of Bcl-2 mRNA.
37.
It was shown that the proliferation of human lymphoma cells ( with t ( 14; 18 ) translocation ) could be inhibited by antisense RNA targeted at the start codon region of Bcl-2 mRNA . In vitro studies led to the identification of Genasense, which is complementary to the first 6 codons of Bcl-2 mRNA.
38.
The fact that the RNA structure is typically found in plasmids suggests that it might be involved in the regulation plasmid copy number by a " cis "-antisense mechanism in a manner similar to that of R1162-like plasmid antisense RNA . However, the " Bacillus "-plasmid RNA motif does not appear to be homologous to any such known RNA.
39.
The "'micF RNA "'is a non-coding RNA stress response gene found in " Escherichia coli " and related bacteria that post-transcriptionally controls expression of the outer membrane porin gene ompF . The micF gene encodes a non-translated 93 nucleotide antisense RNA that binds its target ompF mRNA and regulates ompF expression by inhibiting translation and inducing degradation of the message.
40.
A previously identified motif known as TraJ 5'UTR is also found upstream of " traJ " genes functions as the target of FinP antisense RNAs, so it is possible that " traJ "-II RNAs play a similar role as targets of an antisense RNA . However, some sequence features within the " traJ "-II RNA motif suggest that the biological RNA might be transcribed from the reverse-complement strand.
