In rat models, lesions of the prefrontal cortex have produced increased and protracted response to stress and a lower prepulse inhibition of startle when treated with apomorphine.
32.
Historically, apomorphine has been tried for a variety of uses including psychiatric treatment of homosexuality in the early 20th century, and more recently in treating erectile dysfunction.
33.
New approaches to management include the use of subcutaneous apomorphine, controlled-release preparations of levodopa with a peripheral dopa decarboxylase inhibitor and the continuous intraduodenal administration of levodopa.
34.
Two new drugs for impotence that also can be taken as pills are under development : Zonagen should be out in the fall, Apomorphine early next year, Graham says.
35.
Apomorphine behaves as a partial agonist at D 2S ( efficacies at D 1 and D 5 are unclear, it is known to act as an agonist at these sites.
36.
Some evidence indicates the clinical effects of plants including " N . caerulea " that contain the psychoactive alkaloid apomorphine were known to both the Mayans and the Ancient Egyptians.
37.
Kattau found that one member of the series, LY94939 ( nisoxetine ), was as potent and effective as the TCAs in the reversal of apomorphine-induced hypothermia in mice.
38.
In their research protocol, however, the psychiatrists said the purpose of the study was to explore " schizophrenia subtypes, " based on the patients'response to apomorphine.
39.
The drug, apomorphine, to be sold under the name Apokyn, is the first drug to treat these episodes, which affect about 112, 000 Americans, the agency said.
40.
Apomorphine, a non-orally administered dopamine agonist, may be used to reduce off periods and dyskinesia in late PD . It is administered by intermittent injections or continuous subcutaneous infusions.
