Dr . Colin Rose, an associate professor of medicine at McGill University in Montreal, said : " It looks like Dr . Stamler has discovered the mechanism of autoregulation of blood flow, a problem that has lured many investigators.
32.
These arteries, when healthy, are capable of autoregulation to maintain coronary blood flow at levels appropriate to the needs of the heart attack . ( See also : circulatory system . ) The coronary arteries that run deep within the myocardium are referred to as subendocardial.
33.
Created non-invasive technologies for intracranial pressure measurement, for real-time monitoring of cerebral blood flow autoregulation state, for diagnosing of intracraniospinal compliance, for prediction of hypertension events, etc . are protected by the US, EU, Japan and other patents.
34.
However, due to the important influences of arterial carbon dioxide levels, cerebral metabolic rate, neural activation, activity of the sympathetic nervous system, posture, as well as other physiological variables, cerebral autoregulation is often interpreted as encompassing the wider field of cerebral blood flow regulation.
35.
Cerebral perfusion pressure ( CPP ), the pressure of blood flowing to the brain, is normally fairly constant due to autoregulation, but for abnormal mean arterial pressure ( MAP ) or abnormal ICP the cerebral perfusion pressure is calculated by subtracting the intracranial pressure from the mean arterial pressure : CPP = MAP & minus; ICP.
36.
As a result of that all individual influential factors ( ABP, cerebrovascular autoregulation impairment, individual pathophysiological state of patient, individual diameter and anatomy of OA, hydrodynamic resistance of eyeball vessels, etc . ) do not influence the balance ICP = Pe and, as a consequence, such natural scales do not need calibration.
37.
"' Extraglomerular mesangial cells "'( also known as "'Lacis cells "', "'Goormaghtigh cells "', or "'Polkissen cells "') are light-staining pericytes in the kidney found outside the renal autoregulation of blood flow to the kidney and regulation of systemic blood pressure through the renin-angiotensin system.
38.
Antihypertensive therapy should not be withheld in this setting unless there has been an excessive reduction in BP . A change in medication, however, is indicated if the decline in renal function is temporally related to therapy with an angiotensin ( ACE ) converting enzyme inhibitor or angiotensin II receptor blocker, which can interfere with renal autoregulation and produce acute renal failure in patients with bilateral renal artery stenosis . ( See " Renal effects of ACE inhibitors in hypertension " .)
39.
His research group also worked on the nature of metazoan gene regulation ( Zachar and Bingham, 1985 ) and the elucidation of the first case of autoregulation of gene expression at the level of pre-mRNA splicing ( Chou, et al ., 1987; Zachar, et al ., 1987; Bingham, et al ., 1988; Spikes et al ., 1994 ) and of critical features of the nuclear organization of pre-mRNA processing and transport ( Li and Bingham, 1991; Zachar, et al ., 1994 ).
