A bacterial enzyme with sialic acid mutarotase activity, NanM, that is able to rapidly equilibrate solutions of sialic acid to the resting equilibrium position of around 90 % beta / 10 % alpha has been discovered.
32.
Borinic esters are being researched as bacterial growth inhibitors due to their ability to disable some bacterial enzymes such as menaquinone methyltransferase and CcrM . This may result in development of treatments for topical application on skin.
33.
Using the sortagging protein labeling technique, the researchers used the bacterial enzyme sortase A to establish a strong chemical bond between the surface protein and a substance of choice, such as a small-molecule therapeutic agent or an antibody.
34.
For the body to generate nitric oxide through the nitrate-nitrite-nitric oxide pathway, the reduction of nitrate to nitrite ( by nitrate reductase, a bacterial enzyme ) occurs in the mouth, by commensal bacteria, an obligatory and necessary step.
35.
They showed that restriction was actually due to attack by specific bacterial enzymes on the modified phage s DNA . This work led to the discovery of the class of enzymes now known as " restriction enzymes . " These enzymes allowed controlled manipulation of DNA in the laboratory, thus providing the foundation for the development of genetic engineering.
36.
PFK is about 300 amino acids in length, and structural studies of the bacterial enzyme have shown it comprises two similar ( alpha / beta ) lobes : one involved in ATP binding and the other housing both the substrate-binding site and the allosteric site ( a regulatory binding site distinct from the active site, but that affects enzyme activity ).
