Berberine was supposedly used in China as a folk medicine by Shennong around 3000 BC . This first recorded use of Berberine is described in the ancient Chinese medical book The Divine Farmer's Herb-Root Classic.
32.
Interestingly, there is some evidence for other berberine-containing species synthesizing an efflux pump inhibitor that tends to prevent antibiotic resistance, a case of solid scientific evidence that the herb is superior to the isolated active principle.
33.
When applied " in vitro " and in combination with methoxyhydnocarpin, an inhibitor of multidrug resistance pumps, berberine inhibits growth of " Staphylococcus aureus " and " Microcystis aeruginosa ", a toxic cyanobacterium.
34.
Because you can get at it via berberine as the article explains, and likely by many other humble means, taking it as a protein is an overly expensive approach . talk ) 20 : 56, 28 April 2013 ( UTC)
35.
Recent studies indicate that " M . aquifolium " contains a specific multidrug resistance pump inhibitor ( MDR inhibitor ) named 5'- methoxyhydnocarpin ( 5'- MHC ) which works to decrease bacterial resistance to berberine " in vitro ".
36.
"' 1-Benzylisoquinoline "'is a chemical compound, and the structural backbone of many alkaloids with a wide variety of structures, including papaverine, noscapine, codeine, morphine, apomorphine, berberine, protopine, tubocurarine, and sanguinarine.
37.
Although edible, the plants contain berberine, a compound found in many " Berberis " and " Mahonia " species which can cause vomiting, lowered blood pressure, reduced heart rate, lethargy, and other ill-effects when consumed in large quantities.
38.
When applied to human macrophage-derived foam cells " in vitro ", the dietary supplement berberine inhibits the expression of the ORL1 gene in response to oxidized low-density lipoprotein cholesterol, but this has not yet been demonstrated in a living animal or human.
39.
Berberine alone has weak antibiotic activity " in vitro " since many microorganisms actively export it from the cell ( although a whole herb is likely to work on the immune system as well as on attacking the microbes and hence have a stronger clinical effect than the antibiotic activity alone would suggest ).
40.
Her doctoral dissertation, titled " Investigation of Isoquinoline Alkaloids : Examination of Pictet's Berberine Synthesis ", was completed in 1929 . Outside of these two projects, Davis's research interests included synthesis of alkaloids, catalytic reduction of certain aromatic aldehydes, and Phi Beta Kappa for her distinguished achievements in the field of education.
