In primary sclerosing cholangitis ( PSC ) and primary biliary cirrhosis ( PBC ), the bilirubin references are changed to reflect the fact that these diseases feature high conjugated bilirubin levels.
32.
The differential diagnosis can include primary biliary cholangitis ( formerly referred to as primary biliary cirrhosis ), drug induced cholestasis, cholangiocarcinoma, IgG4-related disease, post-liver transplantation non-anastomotic biliary strictures, and HIV-associated cholangiopathy.
33.
Her contributions to hepatology include seminal work on the natural history of autoimmune hepatitis, variant and overlap syndromes of autoimmune hepatitis, treatment of primary biliary cirrhosis and treatment of viral hepatitis.
34.
Other causes of KF rings are cholestasis ( obstruction of the bile ducts ), primary biliary cirrhosis and " cryptogenic " cirrhosis ( cirrhosis in which no cause can be identified ).
35.
P62 glycosylation is increased in diabetes and may influence its association with other diseases . p62 is also more frequent in Stage IV primary biliary cirrhosis and is prognostic for severe disease.
36.
Established cirrhosis has a 10-year mortality of 34 66 %, largely dependent on the cause of the cirrhosis; alcoholic cirrhosis has a worse prognosis than primary biliary cirrhosis and cirrhosis due to hepatitis.
37.
The autoimmune target of anti-sp100 is the sp100 nuclear antigen which was identified by its association with primary biliary cirrhosis . 20-30 % of patients suffering from primary biliary cirrhosis have sp100 Abs.
38.
The autoimmune target of anti-sp100 is the sp100 nuclear antigen which was identified by its association with primary biliary cirrhosis . 20-30 % of patients suffering from primary biliary cirrhosis have sp100 Abs.
39.
The autoantibodies for this protein are present in the vast majority of patients with primary biliary cirrhosis, a chronic, progressive cholestatic liver disease that usually affects middle-aged women and eventually leads to liver failure.
40.
This is likewise for several genes involved in medical-relevant phenotypes, such as those affecting systemic lupus erythematosus, primary biliary cirrhosis, Crohn's disease, optic disk size, smoking behavior, interleukin 18 levels, and diabetes mellitus type 2.
