With Metrizamide the issue is that if entering the cranial cavity and high dose exposure to the blood brain barrier, side effects are more likely encountered.
32.
Some of the current DNMT inhibitors, however, like zebularine and procainamide, do not cross the blood brain barrier and would not prove as effective a treatment.
33.
Peripheral immune cells are called to the site of injury via these cytokines and may now migrate across the compromised blood brain barrier into the brain.
34.
Difenoxin crosses the blood brain barrier and induces some euphoria; it is often sold with or administered with atropine to reduce the potential for abuse and overdose.
35.
Several companies are trying to develop so-called small-molecule drugs that can be taken orally and pass through the blood brain barrier, but it has not proven easy.
36.
The vascular organ lacks a blood brain barrier, and so neurons in this region can respond to osmotic pressure factors that are present in the systemic circulation.
37.
Positron emission tomography ( PET ) studies, have demonstrated that aprepitant can cross the blood brain barrier and bind to NK 1 receptors in the human brain.
38.
Itopride poorly penetrates across the blood brain barrier because of its high polarity and thus itopride does not tend to cause any central nervous system adverse effects.
39.
Central nervous system adverse effects do not tend to occur due to poor penetration across the blood brain barrier, although a slight raising of prolactin levels may occur.
40.
Classified as a sensory circumventricular organ ( along with the SFO and AP ), It lacks the tight endothelial blood brain barrier, which is characteristic of the CVOs.
