It interacts with the paired amphipathic alpha-helix 2 ( PAH2 ) domain of mSin3, a transcriptional repressor domain that is attached to transcription repressor proteins such as the mSin3A corepressor.
32.
The protein encoded by this gene was identified as an interacting corepressor of BCL6, a POZ / zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis.
33.
The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others.
34.
SAP130 is a subunit of the histone deacetylase ( see HDAC1; MIM 601241 )-dependent SIN3A ( MIM 607776 ) corepressor complex ( Fleischer et al ., 2003 ) . [ supplied by OMIM]
35.
SDS3 is a subunit of the histone deacetylase ( see HDAC1; MIM 601241 )-dependent SIN3A ( MIM 607776 ) corepressor complex ( Fleischer et al ., 2003 ) . [ supplied by OMIM]
36.
LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor ( NR ) box.
37.
Recruitment of corepressors, generally occurring in the absence of ligand, depends on a critical conformation of the receptor AF-2 domain, as well as upon nuclear receptor box-like helical motifs in the corepressor.
38.
The function of PPARs is modified by the precise shape of their ligand-binding domain ( see below ) induced by ligand binding and by a number of corepressor proteins, the presence of which can stimulate or inhibit receptor function, respectively.
39.
The MTA3-NuRD complex represses Snail, a master regulator of epithelial-to-mesenchymal transition ( EMT ), and BCL6-corepressor target genes The MTA3-NuRD complex interacts with GATA3 to regulate the expression of GATA3 downstream targets.
40.
These enzymes catalyze the hydrolysis of acetylated lysine residues restoring the positive charge to histone proteins and hence the tie between histone and DNA . PELP-1 can act as a transcriptional corepressor for transcription factors in the nuclear receptor family such as glucocorticoid receptors.
