There are some conditions affecting the heme groups present in hemoglobin that can make the skin appear blue a symptom called cyanosis.
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The cyanosis is a result of laryngospasm ( a protective mechanism that the body has to prevent aspiration into the trachea ).
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Also, vitamin C can occasionally reduce cyanosis associated with chronic methemoglobinemia but has no role in treatment of acute acquired methemoglobinemia.
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The onset of pulmonary hemorrhage is characterized by cough productive of blood ( hemoptysis ) and worsening of oxygenation leading to cyanosis.
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In his self-portraits the progressive symptoms of his physical deterioration, such as cyanosis and finger clubbing, are apparent.
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Other autonomic manifestations included mydriasis, pallor, cyanosis, tachypnea, hypersalivation, and perspiration at various stages of the ictus.
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But its unacceptable toxic effects, the most alarming being cyanosis due to methemoglobinemia, prompted the search for less toxic aniline derivatives.
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Severe cases can suffer of reduced pulmonary function for some months, the worst cases developing marked dyspnea and cyanosis leading to death.
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Acrocyanosis may be a sign of a more serious medical problem, such as connective tissue diseases and diseases associated with central cyanosis.
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However, if you are linking inside Wikipedia, you can pipelink by making it look like : Common causes of central cyanosis.
