Loxapine may be metabolized by " N "-demethylation to amoxapine, a tetracyclic antidepressant.
32.
Oxymorphone is also a minor metabolite of oxycodone, which is formed by CYP2D6-mediated O-demethylation.
33.
O-demethylation of DXM to DXO contributes to at least 80 % of the DXO formed during DXM metabolism.
34.
Additional demethylation reactions occur in tumor cells, releasing formaldehyde in situ before the drug is excreted in the urine.
35.
Nicodicodeine is metabolised in the liver by demethylation to produce 6-nicotinoyldihydromorphine, and subsequently further metabolised to dihydromorphine.
36.
Tetrahydrofolate here serves as a 1-carbon acceptor during the demethylation process ( See figure 3 for mechanism ).
37.
It has also been suggested that members of the DNA damage repair GADD45 family may contribute to this demethylation process.
38.
Under anaerobic condition and without tetrahydrofolate, however, a free formaldehyde is formed after the N-demethylation of sarcosine.
39.
This demethylation process is the first step in the highly sought-after demethylation pathway of DMSP degradation in marine bacteria.
40.
This demethylation process is the first step in the highly sought-after demethylation pathway of DMSP degradation in marine bacteria.
