Differential expression of miRNAs between healthy tissues and tumors permit to engineer oncolytic viruses in order to have their ability to replicate impaired in those tissues of interest while allowing its replication in the tumor cells.
32.
By analyzing the differential expression of two existing, viable alleles for the X-linked enzyme glucose-6-phosphate dehydrogenase ( G6PD ) gene, Beutler observed that the inactivation of the gene was heritable across passaged generations of the cells.
33.
In 1776 Jean Baptiste Marie Meusnier discovered that the helicoid and catenoid satisfy the equation, and that the differential expression corresponds to twice the mean curvature of the surface, concluding that surfaces with zero mean curvature are area-minimizing.
34.
Moreover, differential expression of miR-127 was detected in different type of DLCL . miR-127 levels were significantly higher in the testicular DLCL compared with the nodal and central nervous system DLCL, implying different biological entity of DLCL in different locations.
35.
The extent of differential expression of miRNAs is even high enough that hierarchical clustering has enabled petitioning of samples within a single developmental lineage reflecting mechanisms of transformation and providing miRNA finger prints that encode the development of typical human cancers.
36.
In contrast to SH-SY5Y neuroblastoma cells, HL60 leukemia cells demonstrated no binding of CERK even in the presence of ATRA . This suggests that differential expression of RAR ?, RXR ?, and COUP-PTI may determine transcription levels in various cell lines.
37.
Expression data is submitted in a multi-column format, the first column identifying the protein, additional columns are expected to be numeric expression values, they can in fact be any numeric value, e . g . differential expression, quantitiative proteomics, GWAS scores.
38.
It was later determined that the Act-1 monoclonal antibody reacted with an alpha-4 / beta-7 integrin that was subsequently shown to interact with a gut-associated addressin, MadCAM . Early work with Yacyshyn showed differential expression in inflammatory bowel disease ( 5 ).
39.
Others have approached their study of the origins of genomic imprinting from a different side, arguing that natural selection is operating on the role of epigenetic marks as machinery for homologous chromosome recognition during meiosis, rather than on their role in differential expression.
40.
The isoforms are produced from alternative splicing at different 5'exons, with the first exon of DUT-N occurring 767 base pairs downstream of the first exon in DUT-M . Regulation at different promoters has been proposed to account for the differential expression of these isoforms.
