Naltrexone won federal approval four and a half years ago _ the first anti-alcoholism drug since the 1948 approval of Antabuse ( disulfiram ).
32.
The reason for this finding was that only 20 % of subjects in disulfiram group were estimated to be in good compliance with the drug regimen.
33.
The term " tippler's bane " is derived from its ability to create acute sensitivity to alcohol, similar to disulfiram ( Antabuse ).
34.
Covalent binding of disulfiram to the thiol blocks the binding of one of the cysteine residues with iodoacetamide, thereby inactivating the enzyme and significantly lowering catalytic activity.
35.
That drug, disulfiram, introduced in 1948 and marketed as Antabuse, is an aversive agent the causes nausea and vomiting in patients who drink while undergoing treatment.
36.
The cysteine residue at 302 in ALDH1 and 200 in ALDH2 is implicated as a disulfiram binding site on the enzyme and serves as a disfulfiram sensitive thiol site.
37.
These symptoms are the same as those observed in people who drink while being treated by the drug disulfiram, which is why it is used to treat alcoholism.
38.
Its effects are similar to the drug disulfiram ( Antabuse ) in that it interferes with the normal metabolism of alcohol by preventing the breakdown of the metabolic byproduct acetaldehyde.
39.
However, in most cases, this disruption is mild and presents itself as a 20 40 % increase in the half-life of the compound at typical dosages of disulfiram.
40.
A recent 9-year study found that incorporation of supervised carbimide and the similar drug, disulfiram, into a comprehensive treatment program resulted in an abstinence rate of over 50 %.
