She based Sabina on characters she knew existed in the 1920s and 1930s carnival sideshows with names like " Lobster Girl " or " Lobster Boy . " These were typically the best jobs people with ectrodactyly could have, with most others being hidden away.
32.
The hands and feet of people with ectrodactyly are often described as " claw-like " and may include only the thumb and one finger ( usually either the little finger, ring finger, or a syndactyly of the two ) with similar abnormalities of the feet.
33.
TP63 mutations underlie several malformation syndromes that include cleft lip and / or palate as a hallmark feature . cleft lip / palate syndrome 3 ( EEC3 ); ectrodactyly ( also known as split-hand / foot malformation 4 ( SHFM4 ) ); ankyloblepharon-ectodermal dysplasia-cleft lip / palate ( AEC ) or Hay Wells syndrome in which a midline cleft lip is also a common feature,
34.
A number of factors make the identification of the genetic defects underlying human ectrodactyly a complicated process : the limited number of families linked to each split hand / foot malformation ( SHFM ) locus, the large number of morphogens involved in limb development, the complex interactions between these morphogens, the involvement of modifier genes, and the presumed involvement of multiple gene or long-range regulatory elements in some cases of ectrodactyly.
35.
A number of factors make the identification of the genetic defects underlying human ectrodactyly a complicated process : the limited number of families linked to each split hand / foot malformation ( SHFM ) locus, the large number of morphogens involved in limb development, the complex interactions between these morphogens, the involvement of modifier genes, and the presumed involvement of multiple gene or long-range regulatory elements in some cases of ectrodactyly.
