| 31. | However, inhaled A1AT may not reach the elastin fibers in the lung where elastase injury actually occurs.
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| 32. | Elastase-like proteases have a much smaller S1 cleft than either trypsin-or chymotrypsin-like proteases.
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| 33. | MMP9, along with elastase, appears to be a regulatory factor in neutrophil migration across the basement membrane.
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| 34. | SLPI is one of the major defenses against the destruction of pulmonary tissues and epithelial tissues by neutrophil elastase.
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| 35. | Gelatinase B, along with elastase, appears to be a regulatory factor in neutrophil migration across the basement membrane.
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| 36. | The activity of elastase is increased by human serum albumin, which is the most abundant protein found in chronic wounds.
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| 37. | However it was later discovered that it was the only chymotrypsin-like elastase that was not expressed in the pancreas.
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| 38. | In humans, neutrophil elastase is encoded by the " ELANE " gene, which resides on chromosome 19.
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| 39. | Neutrophil elastase has been shown to interact with Alpha 2-antiplasmin, which belongs to the Serpin family of proteins.
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| 40. | The genes encoding this protein, neutrophil elastase 2, and proteinase 3 are in a cluster located at chromosome 19pter.
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