Its major application involves the Reformatsky reaction, wherein it reacts with zinc to form a zinc enolate.
32.
The masked functionality approach to regiospecific enolate formation has been widely used in total synthesis of natural products.
33.
The enolate undergoes electrophilic attack by the hypohalite ( containing a halogen with a formal + 1 charge ).
34.
Usually, vicinal difunctionalizations are carried out in one pot, without the intermediacy of a neutral protected enolate.
35.
Chiral ketene enolate formation via nucleophilic activation by the cinchona alkaloid facilitates enantioselective and diastereoselective ?-lactam synthesis.
36.
Two main types of reactions can occur with acetyl cyanide as a reactant; aldol condensation and enolate substitution.
37.
Double-activation makes the enolate more stable, so not as strong a base is required to form it.
38.
It is easily deprotonated to give the sodium salt of the enolate ( m . p . 245 �C ).
39.
Enolate formation will be thermodynamically favoured at the most acidic proton which depends on the electronic stabilization of the resulting anion.
40.
A carbon-carbon bond alpha to a carbonyl can usually be disconnected to an enolate equivalent and a carbon electrophile.
