Fourth, the products of the Sharpless epoxidation are predictable using the Sharpless Epoxidation model discovered by Debbie van Basten.
32.
In the realm of asymmetric methods, both the Sharpless epoxidation and Jacobsen epoxidation surpass asymmetric dioxirane oxidations in enantioselectivity.
33.
In the realm of asymmetric methods, both the Sharpless epoxidation and Jacobsen epoxidation surpass asymmetric dioxirane oxidations in enantioselectivity.
34.
Many scientists have identified Sharpless'epoxidation as the most important discovery in the field of synthesis during the past few decades.
35.
The Sharpless epoxidation has been used for the total synthesis of various carbohydrates, terpenes, leukotrienes, pheromones, and antibiotics.
36.
After a second epoxidation of the ring, the nearby nucleophilic nitrogen attacks the electrophilic carbon, forming a five membered ring.
37.
Their ability to provide stereoinduction has led to use in metal catalyzed hydrogenation, epoxidation, addition, and allylic alkylation reactions.
38.
Its main application is in Sharpless epoxidation, where it serves as a chiral ligand to titanium after reaction with titanium isopropoxide.
39.
With a small ligand such pyridine that binds manganese from inside the cavity of the rotaxane, epoxidation happens outside the catalyst.
40.
The Jacobsen epoxidation, an alternative method to enantioselectively oxidise alkenes, overcomes this issue and tolerates a wider array of functional groups.
