Two years ago, she was diagnosed with Sjogren's Syndrome, an autoimmune disease in which the body's immune system reacts against itself, destroying exocrine glands, including those that secrete saliva and tears.
32.
Acting as a competitive non-selective blocker at postsynaptic and postjunctional muscarinic receptor sites in smooth muscle, exocrine glands, and the brain, BZ decreases the effective concentration of acetylcholine seen by receptors at these sites.
33.
In most exocrine glands, the CFTR protein normally secretes chloride ions into the lumen, and also has a tonic inhibitory effect on the opening of the apical sodium channel ( which absorbs sodium into the cell ).
34.
Epstein-Barr virus, hepatitis C, and human T-cell leukemia virus-1 are among the most studied infectious agents in SS . Damaged self-structures targeted for apoptosis may be mistakenly exposed to the immune system, triggering autoimmunity in exocrine glands which are often prone to autoimmune responses.
35.
House then determines the true cause of the girl's illness based upon her inability to produce tears, a symptom of her illness, candidiasis ( a fungal infection ) secondary to Sj�gren's syndrome, an autoimmune disorder in which immune cells destroy exocrine glands that produce tears and saliva.
36.
Pancreas is both an endocrine and an exocrine gland, in that it functions to produce endocrinic hormones released into the circulatory system ( such as insulin, and glucagon ), to control glucose metabolism, and also to secrete digestive / exocrinic pancreatic juice, which is secreted eventually via the pancreatic duct into duodenum.
37.
Toxicology also manifests in the autonomic nervous system, primarily at the neuromuscular junction, resulting in ataxia and extrapyramidal side-effects and the feeling of heaviness in the legs, and at sympathetic post-ganglionic junctions, causing urinary retention, pupil dilation, tachycardia, irregular urination, and dry red skin caused by decreased exocrine gland secretions, and mucous membranes.
