Phosphorylation of WRN at serine / threonine inhibits helicase and exonuclease activities which are important to post-replication DNA repair.
32.
If a mismatch is detected, a 3'to 5'exonuclease activity is activated and the incorrect base removed.
33.
TaqMan probes, which rely upon the 5'- 3'exonuclease activity of " Taq " polymerase.
34.
However, the 3'to 5'exonuclease activity of DNA polymerase III ensures that mismatched bases are excised during replication.
35.
One possibly explanation for this is that the secondary structure may protect the RNA from 5'- 3'exonuclease activity.
36.
The gua promoter lies back-to-back with the xseA promoter ( encoding the mismatch repair enzyme exonuclease VII ).
37.
Surveyor nuclease also has a 52 exonuclease activity that attacks the ends of double stranded DNA increasing background signal during extended incubation.
38.
The drug is metabolized via exonuclease ( 3-and 5 )-mediated hydrolysis and does not interact with CYP450 enzymes.
39.
This exposes large sections of DNA to exonuclease digestion, allowing for quick excision ( and later replacement ) of the incorrect DNA.
40.
After co-transcriptional endonucleolitical cleavage by Drosha 5'- > 3'exonuclease XRN2 may terminate further transcription by torpedo mechanism.
