The regulation of glutamine synthetase from " E . coli " is a striking demonstration of cumulative feedback inhibition and of control by a cascade of reversible covalent modifications.
32.
Veldhuis JD, Anderson SM, Iranmanesh A, Bowers CY . Testosterone Blunts Feedback Inhibition of Growth Hormone Secretion by Experimentally Elevated Insulin-like Growth Factor-1 Concentration.
33.
Citrate is used for feedback inhibition, as it inhibits phosphofructokinase, an enzyme involved in glycolysis that catalyses formation of fructose 1, 6-bisphosphate, a precursor of pyruvate.
34.
The forms that produce threonine and lysine are subject to feedback inhibition, and all three can be repressed at the level of gene expression by high concentrations of their end-products.
35.
Since malate is formed in the next step of the CAM and C4 cycles after PEP carboxylase catalyses the condensation of CO 2 and PEP to oxaloacetate, this works as a feedback inhibition pathway.
36.
Feedback inhibition of final products is the main method of inhibition, and, in " E . coli ", the " ilvEDA " operon also plays a part in this regulation.
37.
Due to feedback inhibition, a cell is able to know whether the amount of a product is enough for its subsistence or there is a lack of the product ( or there is too much product ).
38.
The " ilvGMEDA " operon ( encoding ALS II, branched-chain-amino-acid transaminase, dihydroxy-acid dehydratase, and threonine ammonia-lyase ) is regulated by feedback inhibition in the form of transcriptional attenuation.
39.
In a microbial process employing an auxotrophic mutant ( nutritionally requiring mutant ), excess supply of the required nutrient results in abundant cell growth with little accumulation of the desired metabolite due to feedback inhibition and / or end-product repression.
40.
Normally there's a system of feedback inhibition in place, which makes it harder for cells to fire if many are firing, but if that system fails for some reason, you get epilepsy . talk ) 22 : 00, 29 August 2006 ( UTC)
